Investigation of pneumonia-causing pathogenic organisms in children and the usefulness of tebipenem pivoxil for their treatment
Identifieur interne : 000764 ( new/Analysis ); précédent : 000763; suivant : 000765Investigation of pneumonia-causing pathogenic organisms in children and the usefulness of tebipenem pivoxil for their treatment
Auteurs : Haruo Kuroki ; Noriko Tateno ; Hiroyuki Ikeda ; Naoko SaitoSource :
- Journal of Infection and Chemotherapy [ 1341-321X ] ; 2010.
Abstract
We investigated the usefulness of the novel oral carbapenem antibiotic tebipenem pivoxil (TBPM-PI) for treating bacterial pneumonia in children. Sputum and nasopharyngeal swabs were collected simultaneously, and causative organisms were identified by conventional bacterial culture together with exhaustive bacterial and viral identification by real-time polymerase chain reaction (PCR). The subjects were eight patients diagnosed with mild or moderate pneumonia at Sotobo Children’s Clinic Outpatient Department between October 2006 and June 2007. TBPM-PI was administered at the recommended clinical dose of 4 mg/kg b.i.d. to five patients and at a high dose of 6 mg/kg b.i.d. to three patients. Sputum was collected from all patients, and 11 strains were detected from washed sputum culture. Causative organisms were mainly
Url:
DOI: 10.1007/s10156-010-0053-9
PubMed: 20352278
PubMed Central: 7087938
Affiliations:
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PMC:7087938Le document en format XML
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<author><name sortKey="Saito, Naoko" sort="Saito, Naoko" uniqKey="Saito N" first="Naoko" last="Saito">Naoko Saito</name>
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<series><title level="j">Journal of Infection and Chemotherapy</title>
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<front><div type="abstract" xml:lang="en"><p>We investigated the usefulness of the novel oral carbapenem antibiotic tebipenem pivoxil (TBPM-PI) for treating bacterial pneumonia in children. Sputum and nasopharyngeal swabs were collected simultaneously, and causative organisms were identified by conventional bacterial culture together with exhaustive bacterial and viral identification by real-time polymerase chain reaction (PCR). The subjects were eight patients diagnosed with mild or moderate pneumonia at Sotobo Children’s Clinic Outpatient Department between October 2006 and June 2007. TBPM-PI was administered at the recommended clinical dose of 4 mg/kg b.i.d. to five patients and at a high dose of 6 mg/kg b.i.d. to three patients. Sputum was collected from all patients, and 11 strains were detected from washed sputum culture. Causative organisms were mainly <italic>Streptococcus pneumoniae</italic>
(3 strains) and <italic>Haemophilus influenzae</italic>
(6 strains), and nasopharyngeal swabs showed the same organisms as coughed-up sputum. Real-time PCR for individual viruses and <italic>Mycoplasma pneumoniae</italic>
identified four cases of only bacterial infection, one case of <italic>M.</italic>
<italic>pneumoniae</italic>
coinfection, two cases of viral coinfection, and one case of both viral and <italic>M.</italic>
<italic>pneumoniae</italic>
coinfection. The clinical results indicated efficacy in all patients, and causative organisms were 100% eliminated. In the four patients with only bacterial infection, the average fever of 38.9°C at the start of treatment normalized the following day, showing excellent efficacy. No clinically problematic adverse events occurred, and compliance was good. We consider that these cases provide valuable insights into the identity of pathogenic organisms of pneumonia in children and the possible role of TBPM-PI in outpatient treatment.</p>
</div>
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